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Albumin-neprilysin fusion protein: understanding stability using small angle X-ray scattering and molecular dynamic simulations

Fusion technology is widely used in protein-drug development to increase activity, stability, and bioavailability of protein therapeutics. Fusion proteins, like any other type of biopharmaceuticals, need to remain stable during production and storage. Due to the high complexity and additional intram...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kulakova, Alina, Indrakumar, Sowmya, Sønderby Tuelung, Pernille, Mahapatra, Sujata, Streicher, Werner W., Peters, Günther H. J., Harris, Pernille
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308280/
https://ncbi.nlm.nih.gov/pubmed/32572086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67002-9
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