Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells

Heat shock can induce either cytoprotective mechanisms or cell death. We found that in certain human and mouse cells, including spermatocytes, activated heat shock factor 1 (HSF1) binds to sequences located in the intron(s) of the PMAIP1 (NOXA) gene and upregulates its expression which induces apopt...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cell Death Differ
Main Authors: Janus, Patryk, Toma-Jonik, Agnieszka, Vydra, Natalia, Mrowiec, Katarzyna, Korfanty, Joanna, Chadalski, Marek, Widłak, Piotr, Dudek, Karolina, Paszek, Anna, Rusin, Marek, Polańska, Joanna, Widłak, Wiesława
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308270/
https://ncbi.nlm.nih.gov/pubmed/31996779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0501-8
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker