Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells

Heat shock can induce either cytoprotective mechanisms or cell death. We found that in certain human and mouse cells, including spermatocytes, activated heat shock factor 1 (HSF1) binds to sequences located in the intron(s) of the PMAIP1 (NOXA) gene and upregulates its expression which induces apopt...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Janus, Patryk, Toma-Jonik, Agnieszka, Vydra, Natalia, Mrowiec, Katarzyna, Korfanty, Joanna, Chadalski, Marek, Widłak, Piotr, Dudek, Karolina, Paszek, Anna, Rusin, Marek, Polańska, Joanna, Widłak, Wiesława
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308270/
https://ncbi.nlm.nih.gov/pubmed/31996779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0501-8
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