Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells

Heat shock can induce either cytoprotective mechanisms or cell death. We found that in certain human and mouse cells, including spermatocytes, activated heat shock factor 1 (HSF1) binds to sequences located in the intron(s) of the PMAIP1 (NOXA) gene and upregulates its expression which induces apopt...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cell Death Differ
Autors principals: Janus, Patryk, Toma-Jonik, Agnieszka, Vydra, Natalia, Mrowiec, Katarzyna, Korfanty, Joanna, Chadalski, Marek, Widłak, Piotr, Dudek, Karolina, Paszek, Anna, Rusin, Marek, Polańska, Joanna, Widłak, Wiesława
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308270/
https://ncbi.nlm.nih.gov/pubmed/31996779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0501-8
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars