LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling

The initiation of puberty is driven by an upsurge in hypothalamic gonadotropin-releasing hormone (GnRH) secretion. In turn, GnRH secretion upsurge depends on the development of a complex GnRH neuroendocrine network during embryonic life. Although delayed puberty (DP) affects up to 2% of the populati...

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Publicat a:JCI Insight
Autors principals: Mancini, Alessandra, Howard, Sasha R., Marelli, Federica, Cabrera, Claudia P., Barnes, Michael R., Sternberg, Michael J.E., Leprovots, Morgane, Hadjidemetriou, Irene, Monti, Elena, David, Alessia, Wehkalampi, Karoliina, Oleari, Roberto, Lettieri, Antonella, Vezzoli, Valeria, Vassart, Gilbert, Cariboni, Anna, Bonomi, Marco, Garcia, Marie Isabelle, Guasti, Leonardo, Dunkel, Leo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308048/
https://ncbi.nlm.nih.gov/pubmed/32493844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133434
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