LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling

The initiation of puberty is driven by an upsurge in hypothalamic gonadotropin-releasing hormone (GnRH) secretion. In turn, GnRH secretion upsurge depends on the development of a complex GnRH neuroendocrine network during embryonic life. Although delayed puberty (DP) affects up to 2% of the populati...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Mancini, Alessandra, Howard, Sasha R., Marelli, Federica, Cabrera, Claudia P., Barnes, Michael R., Sternberg, Michael J.E., Leprovots, Morgane, Hadjidemetriou, Irene, Monti, Elena, David, Alessia, Wehkalampi, Karoliina, Oleari, Roberto, Lettieri, Antonella, Vezzoli, Valeria, Vassart, Gilbert, Cariboni, Anna, Bonomi, Marco, Garcia, Marie Isabelle, Guasti, Leonardo, Dunkel, Leo
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308048/
https://ncbi.nlm.nih.gov/pubmed/32493844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133434
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