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T-cell activation is modulated by the 3D mechanical microenvironment

T cells recognize mechanical forces through a variety of cellular pathways, including mechanical triggering of both the T-cell receptor (TCR) and integrin LFA-1. Here we show that T cells can recognize forces arising from the mechanical rigidity of the microenvironment. We fabricated 3D scaffold mat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biomaterials
Prif Awduron: Majedi, Fatemeh S., Hasani-Sadrabadi, Mohammad Mahdi, Thauland, Timothy J., Li, Song, Bouchard, Louis-S., Butte, Manish J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307918/
https://ncbi.nlm.nih.gov/pubmed/32413594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2020.120058
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