Atorvastatin attenuates TGF-β1-induced fibrogenesis by inhibiting Smad3 and MAPK signaling in human ventricular fibroblasts

Excessive proliferation and myofibroblasts transformation of cardiac fibroblasts play a critical role in the process of cardiac fibrosis. Atorvastatin (ATV), a 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor, is commonly used to treat hypercholesterolemia. It has previously been shown tha...

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Publicado no:Int J Mol Med
Main Authors: Du, Yanfei, Xiao, Haiying, Wan, Jun, Wang, Xinyu, Li, Tao, Zheng, Shuzhan, Feng, Jian, Ye, Qiang, Li, Jiafu, Li, Guang, Fan, Zhongcai
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307817/
https://ncbi.nlm.nih.gov/pubmed/32468059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2020.4607
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