YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis

Like many organs, the kidney stiffens after injury, a process that is increasingly recognized as an important driver of fibrogenesis. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are related mechanosensory proteins that bind to Smad transcription factors,...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Szeto, Stephen G., Narimatsu, Masahiro, Lu, Mingliang, He, Xiaolin, Sidiqi, Ahmad M., Tolosa, Monica F., Chan, Lauren, De Freitas, Krystale, Bialik, Janne Folke, Majumder, Syamantak, Boo, Stellar, Hinz, Boris, Dan, Qinghong, Advani, Andrew, John, Rohan, Wrana, Jeffrey L., Kapus, Andras, Yuen, Darren A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2016
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042658/
https://ncbi.nlm.nih.gov/pubmed/26961347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015050499
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