An Inhibitor of the Mitochondrial Permeability Transition Pore is Toxic in Neonatal Mice and lacks Therapeutic Efficacy Following Neonatal Hypoxia Ischemia in Mice

Neonatal hypoxic ischemic (HI) brain injury causes lifelong neurologic disability. Therapeutic hypothermia (TH) is the only approved therapy that partially mitigates mortality and morbidity. Therapies specifically targeting HI-induced brain cell death are currently lacking. Intracellular calcium dys...

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Pubblicato in:Neuroscience
Autori principali: Fang, Jing, Chavez-Valdez, Raul, Flock, Debbie L., Avaritt, Oliver, Saraswati, Manda, Robertson, Courtney, Martin, Lee J., Northington, Frances J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307715/
https://ncbi.nlm.nih.gov/pubmed/30849447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2019.02.030
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