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Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC
MYC is one of the most important oncogenes and is overexpressed in the majority of cancers. G-quadruplexes are noncanonical four-stranded DNA secondary structures that have emerged as attractive cancer-specific molecular targets for drug development. The G-quadruplex formed in the proximal promoter...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7307421/ https://ncbi.nlm.nih.gov/pubmed/31283877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b02679 |
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