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Merging Asymmetric [1,2]-Additions of Lithium Acetylides to Carbonyls with Type II Anion Relay Chemistry

An enantioselective three-component coupling reaction has been developed, enabling the union of a variety of lithium acetylides and electrophiles exploiting an achiral linchpin via an anionic reaction cascade. This Type II Anion Relay Chemistry tactic is initiated via an enantioselective [1,2]-carbo...

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Bibliografiske detaljer
Udgivet i:Org Lett
Main Authors: O’Brien, Kevin T., Smith, Amos B.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307215/
https://ncbi.nlm.nih.gov/pubmed/31498641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b02959
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