Co-targeting of CXCR4 and hedgehog pathways disrupts tumor-stromal crosstalk and improves chemotherapeutic efficacy in pancreatic cancer

Pancreatic cancer (PC) remains a therapeutic challenge because of its intrinsic and extrinsic chemoresistance mechanisms. Here, we report that C-X-C motif chemokine receptor 4 (CXCR4) and hedgehog pathways cooperate in PC chemoresistance via bidirectional tumor-stromal crosstalk. We show that when P...

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Vydáno v:J Biol Chem
Hlavní autoři: Khan, Mohammad Aslam, Srivastava, Sanjeev Kumar, Zubair, Haseeb, Patel, Girijesh Kumar, Arora, Sumit, Khushman, Moh'd, Carter, James Elliot, Gorman, Gregory Stephen, Singh, Seema, Singh, Ajay Pratap
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307206/
https://ncbi.nlm.nih.gov/pubmed/32358063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011748
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