Innate Intracellular Antiviral Responses Restrict the Amplification of Defective Virus Genomes of Parainfluenza Virus 5

During the replication of parainfluenza virus 5 (PIV5), copyback defective virus genomes (DVGs) are erroneously produced and are packaged into “infectious” virus particles. Copyback DVGs are the primary inducers of innate intracellular responses, including the interferon (IFN) response. While DVGs c...

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Опубликовано в: :J Virol
Главные авторы: Wignall-Fleming, Elizabeth B., Vasou, Andri, Young, Dan, Short, John A. L., Hughes, David J., Goodbourn, Steve, Randall, Richard E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2020
Предметы:
Virus-Cell Interactions
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307174/
https://ncbi.nlm.nih.gov/pubmed/32295916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00246-20
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