Phenotypic Effects of Substitutions within the Receptor Binding Site of Highly Pathogenic Avian Influenza H5N1 Virus Observed during Human Infection

Highly pathogenic avian influenza (HPAI) viruses are enzootic in wild birds and poultry and continue to cause human infections with high mortality. To date, more than 850 confirmed human cases of H5N1 virus infection have been reported, of which ∼60% were fatal. Global concern persists that these or...

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Udgivet i:J Virol
Main Authors: Eggink, Dirk, Spronken, Monique, van der Woude, Roosmarijn, Buzink, Jocynthe, Broszeit, Frederik, McBride, Ryan, Pawestri, Hana A., Setiawaty, Vivi, Paulson, James C., Boons, Geert-Jan, Fouchier, Ron A. M., Russell, Colin A., de Jong, Menno D., de Vries, Robert P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307160/
https://ncbi.nlm.nih.gov/pubmed/32321815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00195-20
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