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The Human Cytomegalovirus Transmembrane Protein pUL50 Induces Loss of VCP/p97 and Is Regulated by a Small Isoform of pUL50

The human cytomegalovirus (HCMV) UL50 gene encodes a transmembrane protein, pUL50, which acts as a core component of the nuclear egress complex (NEC) for nucleocapsids. Recently, pUL50 has been shown to have NEC-independent activities: downregulation of IRE1 to repress the unfolded protein response...

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Pubblicato in:J Virol
Autori principali: Lee, Myoung Kyu, Hyeon, Seokhwan, Ahn, Jin-Hyun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307152/
https://ncbi.nlm.nih.gov/pubmed/32321808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00110-20
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