Oligomerization of the Vesicular Stomatitis Virus Phosphoprotein Is Dispensable for mRNA Synthesis but Facilitates RNA Replication

Nonsegmented negative-strand (NNS) RNA viruses possess a ribonucleoprotein template in which the genomic RNA is sequestered within a homopolymer of nucleocapsid protein (N). The viral RNA-dependent RNA polymerase (RdRP) resides within an approximately 250-kDa large protein (L), along with unconventi...

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Bibliographic Details
Published in:J Virol
Main Authors: Bloyet, Louis-Marie, Morin, Benjamin, Brusic, Vesna, Gardner, Erica, Ross, Robin A., Vadakkan, Tegy, Kirchhausen, Tomas, Whelan, Sean P. J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7307139/
https://ncbi.nlm.nih.gov/pubmed/32321813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00115-20
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