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Src family kinases inhibition by dasatinib blocks initial and subsequent platelet deposition on collagen under flow, but lacks efficacy with thrombin generation.
Kinase inhibitors can pose bleeding risks as platelet signaling evolves during clotting. Using microfluidics (200 s(−1) wall shear rate) to perfuse Factor XIIa-inhibited or thrombin-inhibited whole blood (WB) over collagen ± tissue factor (TF), we explored the potency of the Src family kinase (SFK)...
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| Vydáno v: | Thromb Res |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7306827/ https://ncbi.nlm.nih.gov/pubmed/32480168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2020.05.012 |
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