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Structural and catalytic effects of surface loop-helix transplantation within haloalkane dehalogenase family

Engineering enzyme catalytic properties is important for basic research as well as for biotechnological applications. We have previously shown that the reshaping of enzyme access tunnels via the deletion of a short surface loop element may yield a haloalkane dehalogenase variant with markedly modifi...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Marek, Martin, Chaloupkova, Radka, Prudnikova, Tatyana, Sato, Yukari, Rezacova, Pavlina, Nagata, Yuji, Kuta Smatanova, Ivana, Damborsky, Jiri
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306515/
https://ncbi.nlm.nih.gov/pubmed/32612758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.05.019
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