Structural and catalytic effects of surface loop-helix transplantation within haloalkane dehalogenase family

Engineering enzyme catalytic properties is important for basic research as well as for biotechnological applications. We have previously shown that the reshaping of enzyme access tunnels via the deletion of a short surface loop element may yield a haloalkane dehalogenase variant with markedly modifi...

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Pubblicato in:Comput Struct Biotechnol J
Autori principali: Marek, Martin, Chaloupkova, Radka, Prudnikova, Tatyana, Sato, Yukari, Rezacova, Pavlina, Nagata, Yuji, Kuta Smatanova, Ivana, Damborsky, Jiri
Natura: Artigo
Lingua:Inglês
Pubblicazione: Research Network of Computational and Structural Biotechnology 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306515/
https://ncbi.nlm.nih.gov/pubmed/32612758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.05.019
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