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Design, construction, and expression of recombinant human interferon beta gene in CHO-s cell line using EBV-based expression system

BACKGROUND AND PURPOSE: Codon optimization has been considered as a powerful strategy to increase the expression level of protein therapeutics in mammalian cells. As an empirical approach to study the effects of the codon usage and GC content on heterologous gene expression in suspension adapted Chi...

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Foilsithe in:Res Pharm Sci
Main Authors: Shayesteh, Mohadeseh, Ghasemi, Fahimeh, Tabandeh, Fatemeh, Yakhchali, Bagher, Shakibaie, Mehdi
Formáid: Artigo
Teanga:Inglês
Foilsithe: Wolters Kluwer - Medknow 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306247/
https://ncbi.nlm.nih.gov/pubmed/32582354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1735-5362.283814
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