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Design, construction, and expression of recombinant human interferon beta gene in CHO-s cell line using EBV-based expression system

BACKGROUND AND PURPOSE: Codon optimization has been considered as a powerful strategy to increase the expression level of protein therapeutics in mammalian cells. As an empirical approach to study the effects of the codon usage and GC content on heterologous gene expression in suspension adapted Chi...

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Detalhes bibliográficos
Publicado no:Res Pharm Sci
Main Authors: Shayesteh, Mohadeseh, Ghasemi, Fahimeh, Tabandeh, Fatemeh, Yakhchali, Bagher, Shakibaie, Mehdi
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer - Medknow 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306247/
https://ncbi.nlm.nih.gov/pubmed/32582354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1735-5362.283814
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