Evaluating the Utility of Polygenic Risk Scores in Identifying High-Risk Individuals for Eight Common Cancers

BACKGROUND: Genome-wide association studies have identified common genetic risk variants in many loci associated with multiple cancers. We sought to systematically evaluate the utility of these risk variants in identifying high-risk individuals for eight common cancers. METHODS: We constructed polyg...

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Gepubliceerd in:JNCI Cancer Spectr
Hoofdauteurs: Jia, Guochong, Lu, Yingchang, Wen, Wanqing, Long, Jirong, Liu, Ying, Tao, Ran, Li, Bingshan, Denny, Joshua C, Shu, Xiao-Ou, Zheng, Wei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306192/
https://ncbi.nlm.nih.gov/pubmed/32596635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jncics/pkaa021
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