Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12

BACKGROUND/AIM: Steatohepatitis drives fibrogenesis in alcoholic liver disease. However, recent studies have suggested that hepatic stellate cells (HSC) may regulate the parenchymal cell injury and inflammation that precedes liver fibrosis, although the mechanism remains incompletely defined. Neurop...

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Udgivet i:J Hepatol
Main Authors: Arab, Juan P., Cabrera, Daniel, Sehrawat, Tejasav S., Jalan-Sakrikar, Nidhi, Verma, Vikas K., Simonetto, Douglas, Cao, Sheng, Yaqoob, Usman, Leon, Jonathan, Freire, Mariela, Vargas, Jose I., De Assuncao, Thiago M., Kwon, Jung H., Guo, Yi, Kostallari, Enis, Cai, Qing, Kisseleva, Tatiana, Oh, Youngman, Arrese, Marco, Huebert, Robert C., Shah, Vijay H.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305991/
https://ncbi.nlm.nih.gov/pubmed/32087348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2020.02.005
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