PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel

Severe local acidosis causes tissue damage and pain, and is one of the hallmarks of many diseases including ischemia, cancer, and inflammation. However, the molecular mechanisms of the cellular response to acid are not fully understood. We performed an unbiased RNA interference screen and identified...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Science
Asıl Yazarlar: Yang, Junhua, Chen, Jianan, del Carmen Vitery, Maria, Osei-Owusu, James, Chu, Jiachen, Yu, Haiyang, Sun, Shuying, Qiu, Zhaozhu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305803/
https://ncbi.nlm.nih.gov/pubmed/31023925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav9739
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