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PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel

Severe local acidosis causes tissue damage and pain, and is one of the hallmarks of many diseases including ischemia, cancer, and inflammation. However, the molecular mechanisms of the cellular response to acid are not fully understood. We performed an unbiased RNA interference screen and identified...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Yang, Junhua, Chen, Jianan, del Carmen Vitery, Maria, Osei-Owusu, James, Chu, Jiachen, Yu, Haiyang, Sun, Shuying, Qiu, Zhaozhu
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305803/
https://ncbi.nlm.nih.gov/pubmed/31023925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav9739
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