טוען...

PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel

Severe local acidosis causes tissue damage and pain, and is one of the hallmarks of many diseases including ischemia, cancer, and inflammation. However, the molecular mechanisms of the cellular response to acid are not fully understood. We performed an unbiased RNA interference screen and identified...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Science
Main Authors: Yang, Junhua, Chen, Jianan, del Carmen Vitery, Maria, Osei-Owusu, James, Chu, Jiachen, Yu, Haiyang, Sun, Shuying, Qiu, Zhaozhu
פורמט: Artigo
שפה:Inglês
יצא לאור: 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305803/
https://ncbi.nlm.nih.gov/pubmed/31023925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav9739
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