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PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel
Severe local acidosis causes tissue damage and pain, and is one of the hallmarks of many diseases including ischemia, cancer, and inflammation. However, the molecular mechanisms of the cellular response to acid are not fully understood. We performed an unbiased RNA interference screen and identified...
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| Published in: | Science |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7305803/ https://ncbi.nlm.nih.gov/pubmed/31023925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav9739 |
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