Inactivation of TRP53, PTEN, RB1, and/or CDH1 in the ovarian surface epithelium induces ovarian cancer transformation and metastasis

Ovarian cancer (OvCa) remains the most common cause of death from gynecological malignancies. Genetically engineered mouse models have been used to study initiation, origin, progression, and/or mechanisms of OvCa. Based on the clinical features of OvCa, we examined a quadruple combination of pathway...

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Bibliografiske detaljer
Udgivet i:Biol Reprod
Main Authors: Shi, Mingxin, Whorton, Allison E, Sekulovski, Nikola, Paquet, Marilène, MacLean, James A, Song, Yurong, Van Dyke, Terry, Hayashi, Kanako
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305658/
https://ncbi.nlm.nih.gov/pubmed/31930396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biolre/ioaa008
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