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Inactivation of TRP53, PTEN, RB1, and/or CDH1 in the ovarian surface epithelium induces ovarian cancer transformation and metastasis

Ovarian cancer (OvCa) remains the most common cause of death from gynecological malignancies. Genetically engineered mouse models have been used to study initiation, origin, progression, and/or mechanisms of OvCa. Based on the clinical features of OvCa, we examined a quadruple combination of pathway...

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Detalles Bibliográficos
Publicado en:Biol Reprod
Main Authors: Shi, Mingxin, Whorton, Allison E, Sekulovski, Nikola, Paquet, Marilène, MacLean, James A, Song, Yurong, Van Dyke, Terry, Hayashi, Kanako
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305658/
https://ncbi.nlm.nih.gov/pubmed/31930396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biolre/ioaa008
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