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Repurposing type I–F CRISPR–Cas system as a transcriptional activation tool in human cells
Class 2 CRISPR–Cas proteins have been widely developed as genome editing and transcriptional regulating tools. Class 1 type I CRISPR–Cas constitutes ~60% of all the CRISPR–Cas systems. However, only type I–B and I–E systems have been used to control mammalian gene expression and for genome editing....
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| 發表在: | Nat Commun |
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| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7305327/ https://ncbi.nlm.nih.gov/pubmed/32561716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16880-8 |
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