Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing

Profiling immunoglobulin (Ig) receptor repertoires with specialized assays can be cost-ineffective and time-consuming. Here we report ImReP, a computational method for rapid and accurate profiling of the Ig repertoire, including the complementary-determining region 3 (CDR3), using regular RNA sequen...

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Publicado en:Nat Commun
Autores principales: Mandric, Igor, Rotman, Jeremy, Yang, Harry Taegyun, Strauli, Nicolas, Montoya, Dennis J., Van Der Wey, William, Ronas, Jiem R., Statz, Benjamin, Yao, Douglas, Petrova, Velislava, Zelikovsky, Alex, Spreafico, Roberto, Shifman, Sagiv, Zaitlen, Noah, Rossetti, Maura, Ansel, K. Mark, Eskin, Eleazar, Mangul, Serghei
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305308/
https://ncbi.nlm.nih.gov/pubmed/32561710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16857-7
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