Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing

Profiling immunoglobulin (Ig) receptor repertoires with specialized assays can be cost-ineffective and time-consuming. Here we report ImReP, a computational method for rapid and accurate profiling of the Ig repertoire, including the complementary-determining region 3 (CDR3), using regular RNA sequen...

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Published in:Nat Commun
Main Authors: Mandric, Igor, Rotman, Jeremy, Yang, Harry Taegyun, Strauli, Nicolas, Montoya, Dennis J., Van Der Wey, William, Ronas, Jiem R., Statz, Benjamin, Yao, Douglas, Petrova, Velislava, Zelikovsky, Alex, Spreafico, Roberto, Shifman, Sagiv, Zaitlen, Noah, Rossetti, Maura, Ansel, K. Mark, Eskin, Eleazar, Mangul, Serghei
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305308/
https://ncbi.nlm.nih.gov/pubmed/32561710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16857-7
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