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Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity

Mouse embryos acquire global DNA methylation of their genome during implantation. However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been studied comprehensively. Here we systematically analyze the consequences of genetic inactivation of Dnmt1, Dnmt3a and Dnmt3b on the met...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Dahlet, Thomas, Argüeso Lleida, Andrea, Al Adhami, Hala, Dumas, Michael, Bender, Ambre, Ngondo, Richard P., Tanguy, Manon, Vallet, Judith, Auclair, Ghislain, Bardet, Anaïs F., Weber, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305168/
https://ncbi.nlm.nih.gov/pubmed/32561758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16919-w
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