Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity

Mouse embryos acquire global DNA methylation of their genome during implantation. However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been studied comprehensively. Here we systematically analyze the consequences of genetic inactivation of Dnmt1, Dnmt3a and Dnmt3b on the met...

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Udgivet i:Nat Commun
Main Authors: Dahlet, Thomas, Argüeso Lleida, Andrea, Al Adhami, Hala, Dumas, Michael, Bender, Ambre, Ngondo, Richard P., Tanguy, Manon, Vallet, Judith, Auclair, Ghislain, Bardet, Anaïs F., Weber, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305168/
https://ncbi.nlm.nih.gov/pubmed/32561758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16919-w
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