Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity

Topoisomerase 3β (Top3β) is the only dual-activity topoisomerase in animals that can change topology for both DNA and RNA, and facilitate transcription on DNA and translation on mRNAs. Top3β mutations have been linked to schizophrenia, autism, epilepsy, and cognitive impairment. Here we show that To...

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Argitaratua izan da:Nat Commun
Egile Nagusiak: Joo, Yuyoung, Xue, Yutong, Wang, Yue, McDevitt, Ross A., Sah, Nirnath, Bossi, Simone, Su, Shuaikun, Lee, Seung Kyu, Peng, Wei, Xie, Aoji, Zhang, Yongqing, Ding, Yi, Ku, Wai Lim, Ghosh, Soumita, Fishbein, Kenneth, Shen, Weiping, Spencer, Richard, Becker, Kevin, Zhao, Keji, Mattson, Mark P., van Praag, Henriette, Sharov, Alexei, Wang, Weidong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305123/
https://ncbi.nlm.nih.gov/pubmed/32561719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16884-4
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