Exposure–response analysis of endoxifen serum concentrations in early-breast cancer

PURPOSE: Tamoxifen is part of endocrine therapy in breast cancer treatment. Studies have indicated the use of endoxifen concentrations, tamoxifen active metabolite, to guide tamoxifen efficacy. Three endoxifen thresholds have been suggested (5.9 ng/ml, 5.2 ng/ml and 3.3 ng/ml) for therapeutic drug m...

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Publicat a:Cancer Chemother Pharmacol
Autors principals: Sanchez-Spitman, Anabel Beatriz, Moes, Dirk-Jan A. R., Swen, Jesse J., Dezentjé, Vincent O., Lambrechts, Diether, Neven, Patrick, Gelderblom, Hans, Guchelaar, Henk-Jan
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2020
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305085/
https://ncbi.nlm.nih.gov/pubmed/32468081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-020-04089-x
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