The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency

Subunit vaccines generally proceed through a 4-step in vivo cascade—the DUMP cascade—to generate potent cell-mediated immune responses: (1) drainage to lymph nodes; (2) uptake by dendritic cells (DCs); (3) maturation of DCs; and (4) Presentation of peptide-MHC I complexes to CD8(+) T cells. How the...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Adv
Hauptverfasser: Hong, Xiaoyu, Zhong, Xiaofang, Du, Guangsheng, Hou, Yingying, Zhang, Yunting, Zhang, Zhirong, Gong, Tao, Zhang, Ling, Sun, Xun
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304990/
https://ncbi.nlm.nih.gov/pubmed/32596445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz4462
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