Nuclear softening expedites interstitial cell migration in fibrous networks and dense connective tissues

Dense matrices impede interstitial cell migration and subsequent repair. We hypothesized that nuclear stiffness is a limiting factor in migration and posited that repair could be expedited by transiently decreasing nuclear stiffness. To test this, we interrogated the interstitial migratory capacity...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Heo, Su-Jin, Song, Kwang Hoon, Thakur, Shreyasi, Miller, Liane M., Cao, Xuan, Peredo, Ana P., Seiber, Breanna N., Qu, Feini, Driscoll, Tristan P., Shenoy, Vivek B., Lakadamyali, Melike, Burdick, Jason A., Mauck, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304973/
https://ncbi.nlm.nih.gov/pubmed/32596438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax5083
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