Nuclear softening expedites interstitial cell migration in fibrous networks and dense connective tissues

Dense matrices impede interstitial cell migration and subsequent repair. We hypothesized that nuclear stiffness is a limiting factor in migration and posited that repair could be expedited by transiently decreasing nuclear stiffness. To test this, we interrogated the interstitial migratory capacity...

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Vydáno v:Sci Adv
Hlavní autoři: Heo, Su-Jin, Song, Kwang Hoon, Thakur, Shreyasi, Miller, Liane M., Cao, Xuan, Peredo, Ana P., Seiber, Breanna N., Qu, Feini, Driscoll, Tristan P., Shenoy, Vivek B., Lakadamyali, Melike, Burdick, Jason A., Mauck, Robert L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304973/
https://ncbi.nlm.nih.gov/pubmed/32596438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax5083
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