Distinctive germline expression of class I human leukocyte antigen (HLA) alleles and DRB1 heterozygosis predict the outcome of patients with non-small cell lung cancer receiving PD-1/PD-L1 immune checkpoint blockade

BACKGROUND: Nivolumab is a human monoclonal antibody against programmed cell death receptor-1 (PD-1) able to rescue quiescent tumor infiltrating cytotoxic T lymphocytes (CTLs) restoring their ability to kill target cells expressing specific tumor antigen-derived epitope peptides bound to homologue h...

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發表在:J Immunother Cancer
Main Authors: Correale, Pierpaolo, Saladino, Rita Emilena, Giannarelli, Diana, Giannicola, Rocco, Agostino, Rita, Staropoli, Nicoletta, Strangio, Alessandra, Del Giudice, Teresa, Nardone, Valerio, Altomonte, Maria, Pastina, Pierpaolo, Tini, Paolo, Falzea, Antonia Consuelo, Imbesi, Natale, Arcati, Valentina, Romeo, Giuseppa, Caracciolo, Daniele, Luce, Amalia, Caraglia, Michele, Giordano, Antonio, Pirtoli, Luigi, Necas, Alois, Amler, Evzen, Barbieri, Vito, Tassone, Pierfrancesco, Tagliaferri, Pierosandro
格式: Artigo
語言:Inglês
出版: BMJ Publishing Group 2020
主題:
Immunotherapy Biomarkers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304840/
https://ncbi.nlm.nih.gov/pubmed/32554614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000733
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