CHIR99021 and fibroblast growth factor 1 enhance the regenerative potency of human cardiac muscle patch after myocardial infarction in mice

BACKGROUND: We have shown that genetic overexpression of cell cycle proteins can increase the proliferation of transplanted cardiomyocytes derived from human induced-pluripotent stem cells (hiPSC-CMs) in animal models of myocardial infarction (MI). Here, we introduce a new, non-genetic approach to p...

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Bibliographic Details
Published in:J Mol Cell Cardiol
Main Authors: Fan, Chengming, Tang, Yawen, Zhao, Meng, Lou, Xi, Pretorius, Danielle, Menasche, Philippe, Zhu, Wuqiang, Zhang, Jianyi
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304478/
https://ncbi.nlm.nih.gov/pubmed/32169551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2020.03.003
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