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Stereospecific Synthesis of E-Alkenes through anti-Markovnikov Hydroalkylation of Terminal Alkynes

We have developed a method for stereospecific synthesis of E-alkenes from terminal alkynes and alkyl iodides. The hydroalkylation reaction is enabled by a cooperative action of copper and nickel catalysts and proceeds with excellent anti-Markovnikov selectivity. We demonstrate the broad scope of the...

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Vydáno v:J Am Chem Soc
Hlavní autoři: Hazra, Avijit, Chen, Jason, Lalic, Gojko
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304255/
https://ncbi.nlm.nih.gov/pubmed/31373807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b04800
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