Effect of sirolimus on immune reconstitution following myeloablative allogeneic stemcell transplantation: An ancillary analysis of a randomized controlled trial comparing Tacrolimus/Sirolimus with Tacrolimus/Methotrexate (Blood and Marrow Transplant Clinical Trials Network/BMT CTN 0402)

INTRODUCTION: Although allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy for hematologic neoplasms, one of its limiting toxicities continues to be graft versus host disease, both acute and chronic (aGVHD, cGVHD). Sirolimus is a mammalian target of rapamycin (mTOR)...

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Bibliographische Detailangaben
Veröffentlicht in:Biol Blood Marrow Transplant
Hauptverfasser: Gooptu, Mahasweta, Kim, Haesook T., Howard, Alan, Choi, Sung W., Soiffer, Robert J., Antin, Joseph H., Ritz, Jerome, Cutler, Corey S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304072/
https://ncbi.nlm.nih.gov/pubmed/31271885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2019.06.029
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