Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor binding domain (RBD) recognizes angiotensin-converting enzyme 2, initiating conformational changes that drive membrane fusion. We find that th...

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Publicat a:Cell Host Microbe
Autors principals: Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303615/
https://ncbi.nlm.nih.gov/pubmed/32585135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.06.010
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