Comparison of host immune responses to LPS in human using an immune profiling panel, in vivo endotoxemia versus ex vivo stimulation

Patients that suffer from sepsis exhibit an early hyper-inflammatory immune response which can lead to organ failure and death. In our study, we assessed the immune modulation in the human in vivo endotoxemia model and compared it to ex vivo LPS stimulation using 38 transcriptomic markers. Blood was...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Tawfik, Dina M., Lankelma, Jacqueline M., Vachot, Laurence, Cerrato, Elisabeth, Pachot, Alexandre, Wiersinga, W. Joost, Textoris, Julien
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303162/
https://ncbi.nlm.nih.gov/pubmed/32555232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66695-2
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