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Comparison of host immune responses to LPS in human using an immune profiling panel, in vivo endotoxemia versus ex vivo stimulation

Patients that suffer from sepsis exhibit an early hyper-inflammatory immune response which can lead to organ failure and death. In our study, we assessed the immune modulation in the human in vivo endotoxemia model and compared it to ex vivo LPS stimulation using 38 transcriptomic markers. Blood was...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Tawfik, Dina M., Lankelma, Jacqueline M., Vachot, Laurence, Cerrato, Elisabeth, Pachot, Alexandre, Wiersinga, W. Joost, Textoris, Julien
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303162/
https://ncbi.nlm.nih.gov/pubmed/32555232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66695-2
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