Ultrafine silicon dioxide nanoparticles cause lung epithelial cells apoptosis via oxidative stress-activated PI3K/Akt-mediated mitochondria- and endoplasmic reticulum stress-dependent signaling pathways

Silicon dioxide nanoparticles (SiO(2)NPs) are widely applied in industry, chemical, and cosmetics. SiO(2)NPs is known to induce pulmonary toxicity. In this study, we investigated the molecular mechanisms of SiO(2)NPs on pulmonary toxicity using a lung alveolar epithelial cell (L2) model. SiO(2)NPs,...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lee, Kuan-I, Su, Chin-Chuan, Fang, Kai-Min, Wu, Chin-Ching, Wu, Cheng-Tien, Chen, Ya-Wen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303152/
https://ncbi.nlm.nih.gov/pubmed/32555254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66644-z
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