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RelB regulates the homeostatic proliferation but not the function of Tregs

BACKGROUND: RelB, a member of the NF-κB family, plays a critical role in the development of T cells. However, the role of RelB in Foxp3(+) regulatory T cells (Tregs) remains controversial. RESULTS: Using a bone marrow chimeric mouse model, we demonstrated that the expansion of Foxp3(+) Tregs in vivo...

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Detalhes bibliográficos
Publicado no:BMC Immunol
Main Authors: Zhou, Shuping, Wu, Weiwei, Wang, Zhaoxia, Wang, Zhaopeng, Su, Qinghong, Li, Xiaofan, Yu, Yong, Zhang, Weidong, Zhu, Mingzhao, Lin, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7302365/
https://ncbi.nlm.nih.gov/pubmed/32552667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-020-00366-9
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