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SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes

Despite its overwhelming clinical importance, the SARS-CoV-2 gene set remains unresolved, hindering dissection of COVID-19 biology. Here, we use comparative genomics to provide a high-confidence protein-coding gene set, characterize protein-level and nucleotide-level evolutionary constraint, and pri...

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Bibliografske podrobnosti
izdano v:bioRxiv
Main Authors: Jungreis, Irwin, Sealfon, Rachel, Kellis, Manolis
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7302193/
https://ncbi.nlm.nih.gov/pubmed/32577641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.06.02.130955
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