An Exploratory Analysis of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition and Aortic Stenosis in the FOURIER Trial

IMPORTANCE: Despite recent advances in treatment of severe aortic valve stenosis (AS), AS remains a life-threatening condition with no proven disease-modifying therapy. Low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp[a]) have been implicated in the pathobiology of AS. The proprote...

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Vydáno v:JAMA Cardiol
Hlavní autoři: Bergmark, Brian A., O’Donoghue, Michelle L., Murphy, Sabina A., Kuder, Julia F., Ezhov, Marat V., Češka, Richard, Gouni-Berthold, Ioanna, Jensen, Henrik K., Tokgozoglu, S. Lale, Mach, François, Huber, Kurt, Gaciong, Zbigniew, Lewis, Basil S., Schiele, Francois, Jukema, J. Wouter, Pedersen, Terje R., Giugliano, Robert P., Sabatine, Marc S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Association 2020
Témata:
Brief Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7301224/
https://ncbi.nlm.nih.gov/pubmed/32347887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamacardio.2020.0728
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