Association Between Circulating Baseline Proprotein Convertase Subtilisin Kexin Type 9 Levels and Efficacy of Evolocumab

IMPORTANCE: Levels of proprotein convertase subtilisin kexin type 9 (PCSK9) vary markedly across the population and are influenced by genetic and nongenetic factors. Evolocumab is a fully human, monoclonal antibody against PCSK9 that reduces low-density lipoprotein cholesterol (LDL-C) levels by 55%...

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Vydáno v:JAMA Cardiol
Hlavní autoři: Desai, Nihar R., Giugliano, Robert P., Wasserman, Scott M., Gibbs, John P., Liu, Thomas, Scott, Rob, Sabatine, Marc S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Association 2017
Témata:
Brief Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814982/
https://ncbi.nlm.nih.gov/pubmed/28122070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamacardio.2016.5395
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