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H/D Exchange Characterization of Silent Coupling: Entropy-Enthalpy Compensation in Allostery

The allosteric coupling constant in K-type allosteric systems is defined as a ratio of the binding of substrate in the absence of effector to the binding of the substrate in the presence of a saturating concentration of effector. As a result, the coupling constant is itself an equilibrium value comp...

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Vydáno v:Biophys J
Hlavní autoři: Prasannan, Charulata B., Gmyrek, Aleksandra, Martin, Tyler A., Villar, Maria T., Artigues, Antonio, Lee, James Ching, Fenton, Aron W.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7300342/
https://ncbi.nlm.nih.gov/pubmed/32479745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.05.012
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