Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction

The blood-brain barrier (BBB) is a dynamic component of the brain-vascular interface that maintains brain homeostasis and regulates solute permeability into brain tissue. The expression of tight junction proteins between adjacent endothelial cells and the presence of efflux proteins prevents entry o...

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Udgivet i:Sci Rep
Main Authors: Nzou, Goodwell, Wicks, Robert T., VanOstrand, Nicole R., Mekky, Gehad A., Seale, Stephanie A., EL-Taibany, Aya, Wicks, Elizabeth E., Nechtman, Carl M., Marotte, Eric J., Makani, Vishruti S., Murphy, Sean V., Seeds, M. C., Jackson, John D., Atala, Anthony J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299970/
https://ncbi.nlm.nih.gov/pubmed/32555384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66487-8
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