Transient Receptor Potential Vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH Oxidase 4

Asthma is characterized by pathological airway remodeling resulting from persistent myofibroblast activation. Although transforming growth factor beta 1 (TGFβ1), mechanical signals, and reactive oxygen species (ROS) are implicated in fibroblast differentiation, their integration is still elusive. We...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Al-Azzam, Nosayba, Teegala, Lakshminarayan Reddy, Pokhrel, Sabita, Ghebreigziabher, Samrawit, Chachkovskyy, Tatiana, Thodeti, Sathwika, Gavilanes, Ignacio, Covington, Kayla, Thodeti, Charles K., Paruchuri, Sailaja
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299963/
https://ncbi.nlm.nih.gov/pubmed/32555397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66617-2
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