Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

Estrogen receptor (ER) positive breast cancer is frequently sensitive to endocrine therapy. Multiple mechanisms of endocrine therapy resistance have been identified, including cancer stem-like cell (CSC) activity. Here we investigate SFX-01, a stabilised formulation of sulforaphane (SFN), for its ef...

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Udgivet i:Oncogene
Main Authors: Simões, Bruno M., Santiago-Gómez, Angélica, Chiodo, Chiara, Moreira, Tiago, Conole, Daniel, Lovell, Scott, Alferez, Denis, Eyre, Rachel, Spence, Katherine, Sarmiento-Castro, Aida, Kohler, Bertram, Morisset, Ludivine, Lanzino, Marilena, Andò, Sebastiano, Marangoni, Elisabetta, Sims, Andrew H., Tate, Edward W., Howell, Sacha J., Clarke, Robert B.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299846/
https://ncbi.nlm.nih.gov/pubmed/32472077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1335-z
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